NOS1 and ischemic stroke: Although it may seem counter-intuitive to treat a condition that is primarily one of insufficient blood flow (i.e., ischaemic stroke) with a drug that acts to decrease brain perfusion, it is important to consider that (a) nNOS inhibition is being considered as a potential therapy for post-reperfusion excitotoxicity and would only be given once adequate reperfusion had been achieved, and (b) nNOS-derived NO is one of a number of molecules implicated in the regulation of cerebral blood flow and the effect of nNOS inhibition on cerebral blood flow is modest.