BCL2 and melanoma: One such compound, FKB, has been shown to induce autophagy in melanoma cells by causing the accumulation of microtubule-associated protein 1A/1B and light chain 3B (LC3B), downregulating the expressions of protein kinase B (AKT)/mammalian target of rapamycin (mTOR), and disrupting Bcl-1/Bcl-2 levels [98].