It has been reported that three mutants, located in the EL3, p.Val507Ile, p.Val575Met, and p.Tyr526Cys, are associated with the development of Fuchs endothelial corneal dystrophy (FECD), which may be caused by mutations in this region disrupting the structure of SLC4A11 [14]. This evidence concerns the gene SPTB and Fuchs endothelial corneal dystrophy.