TNF and allergic disease: The activation and migration of eosinophils towards the inflammation site are mediated by type 2 T helper cytokines, such as interleukin (IL) 5, IL 13, IL 4, and tumor necrosis factor (TNF), and chemokines, such as eotaxins 1 and 3, and α4β7 integrin, which are released in presence of tissue damage, allergic reactions, or infections [28].