On the other hand, some ZNFs were oppositely regulated in GES-1 infected cells with respect to what was observed in gastric cancer; this was the case, for example, for KLF4, KLF6, KLF9, GLI2, and TNFAIP3, which participate in cellular processes such as cell cycle, cell proliferation, epithelial to mesenchymal transition, invasion and metastasis, apoptosis, and inflammation. The gene discussed is KLF4; the disease is gastric cancer.