ZNFs playing a role in inflammation (i.e., ZHX2), cell proliferation, epithelial to mesenchymal transition, invasion and metastasis (i.e., ZC3H15, ZBTB20, RNF114, ZEB2), drug resistance and cell cycle (i.e., GLIS2), apoptosis, epithelial to mesenchymal transition, and invasion and metastasis (i.e., RNF43) were up- or downregulated as early as 6 h after infection with H. pylori in comparison to non-infected cells in our experimental setting. Here, GLIS2 is linked to infection.