Likewise, Ribeiro and colleagues demonstrated that the expression of two metalloproteases (MMP2 and MMP9) was increased in conditioned media derived from PPAT explants of overweight PCa patients as compared with normo-weight patients with BPH [25] which was also confirmed in our study after normalization of the data by IRGs (Figure 6c,d). This evidence concerns the gene MMP2 and posterior cortical atrophy.