To investigate the role of ferroptosis in the prognosis and immunology of pan-cancer, key regulators of ferroptosis, solute vector family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), and apoptosis-inducing factor mitochondria-associated 2 (AIFM2) were analyzed using TIMER, gene expression profile interaction analysis (GEPIA), Oncomine, and Kaplan–Meier databases. This evidence concerns the gene GPX4 and cancer.