TNF-α has been recognized as a mediator of insulin resistance due to the observed actions of decreasing the activity of the tyrosine kinase of the insulin receptor by promoting the serine phosphorylation of insulin receptor substrate 1 (IRS-I) [30] and reducing the expression of glucose transporter 4 (GLUT 4) in the adipose tissue [31]. The gene discussed is INSR; the disease is Insulin resistance.