Similarly, Omura et al. confirmed the prognostic potential of both sPD-L1 and mPD-L1 in stage I–III CRC patients, where elevated preoperative sPD-L1 levels were significantly correlated with lymphatic invasion, and both high tumoral mPD-L1 and elevated preoperative sPD-L1 were significantly associated with shorter overall survival and disease-free survival [24]. The gene discussed is SPDL1; the disease is colorectal carcinoma.