Resveratrol has been linked to upregulated adiponectin levels to prevent myocardial ischemia injury in diabetic mice [55], whereas berberine studies in diabetic cardiomyopathic rats have showed attenuated hypertrophy via activated AMPK and reduced GSK3β (glycogen synthase kinase 3 beta) [56]. The gene discussed is GSK3B; the disease is myocardial ischemia.