Adverse growth conditions, e.g., iron deficiency, severe stress (heat shock, hydrostatic pressure, osmotic stress) that deplete cellular energy (both Mg2+ and ATP) or bacteriophage infection [12], may apply sufficient selective pressure to entrench H+-dependent Mn2+ import function within the Slc11 synapomorphy-based 3D framework. This evidence concerns the gene SLC34A1 and Iron deficiency anemia.