Regarding spatial ITH, TME was markedly different in T cells in ovarian tumors compared to omental metastases, with an immunosuppressive environment consisting of Tregs and exhausted CD8+ T and CD4+ T cells in the local ovarian ecosystem and TILs composed of non-tumor-specific bystander cells with little evidence for response to tumor-specific antigens in omental lesions [76]. Here, CD4 is linked to neoplasm.