Since the IL-17 activation of MAPKs and the Akt signaling pathway has been reported to be associated with proliferation and metastasis in lung cancer cells, we investigated the effect of notopterol on the IL-17-induced activation of Akt and MAPKs, including ERK1/2, p38, and JNK, using Western blot analysis. This evidence concerns the gene AKT1 and lung cancer.