Another retrospective analysis of 513 patients with LC (83.8% LUADs) described TP53 mutation in 53.6% of the cases using somatic NGS assay, 2.3% of these corresponding to the R337H variant (12 patients), which had a statistical association to EGFR and HER2 alterations [16]. This evidence concerns the gene ERBB2 and laryngotracheoesophageal cleft.