Several proteins involved in glucose metabolism have been linked to type 2 diabetes, including, Glutamine fructose-6-phosphate amidotransferase (GFPT or GFAT), Mono-ADP-ribosyltransferase sirtuin-6 (SIRT6), 11-β hydroxysteroid dehydrogenase type 1 (11β-HSD1) and protein phosphatase (PPM1B) [154]. The gene discussed is SIRT6; the disease is type 2 diabetes mellitus.