Discrete enzyme targets have been identified, comprising cholinesterases such as acetylcholinesterase (AChE), which hydrolyses acetylcholine, and butyrylcholinesterase (BuChE), which acts as a co-regulator of the acetylcholine level and affects beta-secretase, glycogen synthase kinase-3b, and NADPH, which play vital roles in the pathogenesis of AD [23]. Here, ACHE is linked to Alzheimer disease.