Different types of oral hypoglycemic agents, including insulin, thiazolidinediones, sulfonylureas, glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase-4 inhibitors, metformin, meglitinides, sodium-glucose cotransporter 2 inhibitors, and pramlintide are used to treat T2DM [3]. Here, INS is linked to type 2 diabetes mellitus.