For example, DOP suppresses the development of colorectal cancer (CRC) induced via AOM/DSS through augmenting the metabolic function of tumor-infiltrating CD8(+) cytotoxic T-lymphocytes (CTLs) and downregulating the expression of PD-1 in the CTLs, thereby bolstering the anti-tumor immune response [33]. The gene discussed is CD8A; the disease is infectious otitis media.