ACHE and early-onset autosomal dominant Alzheimer disease: Keeping in mind the biological importance of benzimidazole [28,29,30] and oxazole [31] scaffolds (Figure 4), in this study, we designed and synthesized hybrid analogues based on benzimidazole-bearing oxazole derivatives to further explore the AChE and BuChE inhibition profiles for the better treatment of Alzheimer’s disease.