TNFRSF1A and rectum adenocarcinoma: Interestingly, an investigation by Smithson et al. revealed that radiation-induced ST6Gal-1 affects the function of pro-apoptotic proteins, including tumor necrosis factor receptor 1 (TNFR1) and the Fas receptor in rectal adenocarcinoma, resulting in the decreased propagation of apoptotic signaling [124].