In their prospective study on 142 patients, Tang et al. found lower HO-1 levels in the LSCC group compared to control ones (p-value < 0.001) and that HO-1 levels are inversely correlated with advanced tumor stages (p-value < 0.019) and lymph node metastases (p-value < 0.001) [50]. Here, HMOX1 is linked to neoplasm.