In particular, the binding of zinc by the MTs can lead to the following possible effects: (1) zinc promotes G1/S phase transition; therefore, low MT levels may arrest cancer cells in the G1 phase, inhibiting their proliferation, and (2) zinc is fundamental for the transcription of tumor suppressor protein as p53; therefore, high MT levels may remove zinc from p53, causing its inhibition and promoting uncontrolled cancer cell growth [34]. The gene discussed is TCHP; the disease is cancer.