The prediction model established based on preoperative MRI radiomics in this study can basically realize the prospective, non-invasive, and accurate diagnosis of diffuse astrocytic glioma, IDH wild-type, with molecular features of glioblastoma, WHO grade 4 (DAG-G), which is of great significance to help optimize the treatment plan for such patients, including expanding the extent of surgery and actively administering radiotherapy, targeted therapy, or other treatments after surgery, so as to fundamentally maximize the prognosis of patients. The gene discussed is IDH2; the disease is glioblastoma.