NPM1 and anaplastic large cell lymphoma: Although NPM1-ALK is a major ALK fusion protein found in patients with ALCL (accounting for 80% of all ALK+ ALCL cases), several other ALK fusion partners have been discovered, including tropomyosin 3 (TPM3), 5-aminoimidazole-4-carboxamide ribonucleotide (ATIC), and TRK-fused gene (TFG) [4].