Another study on MCC prognostic factors reported that virus negativity correlates with a higher prevalence of ulcerations, high neutrophil/CD8+ ratio, and E-cadherin downregulation, which are considered to have a negative prognostic value since they induce a tumor-promoting microenvironment by suppressing the infiltration of the CD8+ lymphocytes [50]. The gene discussed is CD8A; the disease is neoplasm.