HIF1A and neoplasm: Biological features that impact or reflect tumor vasculature, such as the microvessel density (MVD), hypoxia markers such as HIF-1α, or angiogenesis-promoting vascular endothelial growth factor (VEGF), are bound to affect diffusion and perfusion parameters as determined using functional MRI and have, therefore, been the subject of “radiogenomic” studies [5,6,7].