Extravasation of melanoma cells is promoted by adhesive interaction between the integrin very late antigen (VLA)-4 on melanoma cells and the immunoglobulin (Ig)-like cell adhesion molecule VCAM-1 on endothelial cells, as previously shown for the BBB [17] and other types of endothelial layers [18,19]. This evidence concerns the gene VCAM1 and melanoma.