On the other hand, the average age of CRC onset in our cohort was 38.1 years (range 32–54) for MSH2 PV/LPV carriers and 49.5 years (range 38–61) for PMS2 carriers, which are lower than the average age of CRC onset reported in the NCCN guidelines [29]. Here, MSH2 is linked to colorectal carcinoma.