However, the possibility that the very strong tumorigenic stimulus of the overexpression of Myc in Hi-Myc+/− mouse could result in insensitivity to NSAID-inhibition of PCa formation is negated by the fact that there is also increased expression of c-Myc in TMPRSS2-ERG-driven PCa model [12]. The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.