TMPRSS2 and posterior cortical atrophy: Additional studies are warranted to critically assess the effects of the NSAIDs on inflammatory signaling pathways and inflammatory/immune cell type infiltration-subtype in the prostate tissue and to elucidate the mechanistic reason behind the preventive efficacy of NSAIDs and seemingly superior efficacy of non-aspirin NSAID naproxen compared to aspirin in the TMPSS2-ERG-driven PCa model, but not in the non-TMPRSS2-ERG-driven PCa model.