Given that the promoter elements of TMPRSS2 are androgen-sensitive and that as a result of TMPRSS2-ERG fusion, the androgen-bound androgen receptor binds to TMPRSS2 regions, and the downstream cascade of events is initiated for ERG overexpression [36]; thus, there is a considerable likelihood that the NSAID-mediated decrease in AR expression could also be an important factor impacting the inhibitory effect of NSAIDs on fusion-driven PCa. This evidence concerns the gene ERG and posterior cortical atrophy.