Notably, in the present study, treatment with both NSAIDs, aspirin and naproxen, showed strong efficacy in reducing prostate tumorigenesis in the TMPRSS2-ERG-driven PCa model (although there was no dose-dependent effect), but not in the non-TMPRSS2-ERG-driven (Hi-Myc+/− mouse) PCa model. Here, TMPRSS2 is linked to posterior cortical atrophy.