TMPRSS2 and posterior cortical atrophy: In the present study, employing relevant TMPRSS2-ERG (fusion)-driven and non-TMPRSS2-ERG-driven mouse models of PCa, we report the potential usefulness of the non-steroidal anti-inflammatory drugs (NSAIDs) aspirin and naproxen specifically against TMPSS2-ERG fusion-driven prostate tumorigenesis.