KLK3 and posterior cortical atrophy: Interestingly, a combination strategy of weekly calcitriol (45 μg per week) and daily naproxen (375 mg, twice daily) in a phase II trial of PCa patients, who had a biochemical recurrence based on increasing prostate-specific antigen (PSA) levels, showed an increase in PSA doubling time in 75% of the patients [40].