The data strongly suggested that treatment with NSAIDs results in decreased proliferation of PCa tumor cells, specifically in the TMPRSS2-ERG fusion-positive mice, and thus, corroborated the histopathological observations, which indicated that the NSAIDs also caused a significant arrest of PCa tumor progression in TMPRSS2-ERG fusion-positive mice but not in the Hi-Myc+/− mice. Here, ERG is linked to posterior cortical atrophy.