From the molecular analysis (IHC-based evaluation) of the prostate tissue samples, differential molecular effects of NSAIDs treatment in both mouse models were observed; however, the biological basis of the strong efficacy of both aspirin and naproxen treatments in reducing prostate tumorigenesis in only the TMPSS2-ERG fusion-driven PCa model could not be ascertained. Here, ERG is linked to posterior cortical atrophy.