TSC2 and neoplasm: Among the proteins that were significantly upregulated in the tumor periphery were Ki-67 and components of the PI3K/AKT/mTOR signaling network such as phospho-GSK3A (S21)/phospho-GSK3B (S9), INPP4B, PLCG1, phospho-PRAS40 (T246), phospho-Tuberin (T1462) and phospho-GSK3B (S9), which confirms previous findings [7].