Lymph node metastasis and high YAP1 expression showed significant association with the ODX low-risk group of RS < 26 (lymph node metastasis: OR 0.189, 95%CI 0.067–0.536, p = 0.002; high YAP1: OR 0.302, 95% CI 0.172–0.528, p < 0.001). Here, YAP1 is linked to metastatic malignant neoplasm in the lymph nodes.