USP53 induces apoptosis of hepatocellular carcinoma cells through deubiquitination of cytochrome C [8] and is a tumor suppressive factor in esophageal carcinoma [9], lung adenocarcinoma [10], and renal clear cell carcinoma [11], but it has a significant inhibitory effect on the radiosensitivity of human cervical cancer [12]. The gene discussed is USP53; the disease is clear cell renal carcinoma.