KRAS and neoplasm: Moreover, in murine models of KRAS G12D-mutated PDAC, RMC-9805 decreased tumor infiltration by immunosuppressive myeloid cells, increased T cell infiltration, led to increased major histocompatibility complex (MHC) expression and antigen presentation, downregulation of immune checkpoint inhibitors, and increased T Cell Receptor (TCR) repertoire diversity [130].