SPINK1 and chronic kidney disease: The comparisons between the different subgroups of prostate acinar ADK according to ERG/SPINK1 status, regarding the association of preoperative CKD stage with the prognostic grade groups, revealed significantly more CKD Stage 1 cases with prognostic grade Group 2 in the E+S− subgroup as compared to the E−S+ subgroup (p = 0.03) (Table 8).