HIF1A and neoplasm: This has been clearly shown in the context of HCC, where HIF1 induces the overexpression of ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2/CD39L1) in cancer cells, which impairs the myeloid-derived suppressor cell differentiation, leading to their accumulation in the tumour microenvironment [12].