Possible mechanisms underlying the association between downregulation of ENOB and cancer can include the influence of ENOB on the protein level of β-catenin, while the JAK/STAT and PI3K/AKT signaling pathways remained unaffected, as found by a recent study exploring the association between downregulation of ENOB and HCC [53]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.