They are both high-grade neuroendocrine cancers with similar histological features, including a high mitotic rate, extensive necrosis, and frequent expression of neuroendocrine markers such as synaptophysin, chromogranin-A, and CD56/NCAM (neural cell adhesion molecule) [5,6,7,8,9]. The gene discussed is NCAM1; the disease is neuroendocrine carcinoma.