EGFR and neoplasm: In a meta-analysis of 3110 patients of the diagnostic value of ctDNA vs tumour tissue, ctDNA was a highly specific and effective biomarker for the detection of EGFR mutation status, with a pooled sensitivity and specificity of 0.620 (95% CI 0.513–0.716) and 0.959 (95% CI 0.929–0.977), respectively [27].