Taken further, we find that the distribution of genes co-targeted by MYC, MAX, MXD4, and KDM5B have significantly higher POLR3G correlation scores in cancer, and these overlapping gene targets are enriched for factors that are similarly important for growth, including ribosome, spliceosome, and (other) RNA polymerase subunits (Figure 5b,c). This evidence concerns the gene MXD4 and cancer.