Molecular studies using three different PrPC constructs, NH2-terminal deleted (PrPΔN), Octarepeat-copper binding region (PrPΔOR), and C-terminal deleted (PrPΔC), confirmed the critical role of the N-terminal region of the PrPC protein in promoting the invasive properties of gastric cancer cells [34,77]. Here, PRNP is linked to gastric cancer.