HK1 and cancer: It is possible that the proliferation and migration of M12.CB3 cells are attenuated by JunBlo microglia-derived factors through a reduction in ALDOC transcription, as we previously demonstrated that microglia-derived factors increased the proliferation of M12.CB3 cells overexpressing the glycolytic enzyme ALDOC [21], which is essential for cancer cell proliferation and migration [83,84].