RNA-seq analysis of mRNA extracted from microglia cells treated with melanoma-conditioned medium (MCM) or with starvation medium (control) for 3 or 24 h identified 621 and 1353 genes differentially expressed in microglia cells treated with DP.CB2-conditioned medium (CM) for 3 or 24 h, correspondingly, compared to the control microglia cells, and 504 and 663 genes differentially expressed in microglia cells treated with M12.CB3 CM for 3 or 24 h, correspondingly (pAdj < 0.05 and FC ≤ −2 or FC ≥ 2). This evidence concerns the gene CNR2 and melanoma.