HIF1A and hepatocellular carcinoma: In respect of signalling molecule-mediated crosstalk, it has been shown that in hypoxic and inflammatory conditions, M2-like TAMs secrete high amounts of IL-1β, inducing an overexpression of hypoxia inducible factor (HIF)-1α in HCC cells, the latter being responsible of an increased EMT of HCC cells and HCC metastasis in mouse models [65].