GPC3 and hepatocellular carcinoma: Regarding their potential applicability in HCC, a liver macrophage-targeting mRNA-laden lipid nanoparticle (LNP) was recently generated to produce CAR-Ms coexpressing glypican-3 (GPC3)-specific CAR, a glycoprotein attached and extensively upregulated in HCC tissues, and Siglec-G lacking immunoreceptor tyrosine-based inhibition motifs (Siglec- GΔITIMs).