IL6 and hepatocellular carcinoma: On the other hand, the secretion of reactive nitrogen species (RNS) such as nitric oxide (NO), which were shown to be regulated by the transcription factor forkhead box O-1 (FOXO1) in HCC cells, modulates TAM infiltration and polarization towards an antitumour phenotype by reducing IL-6 and CD206 expression in these macrophages [53].