We previously developed a mouse model of BRAFV600E-driven spontaneous melanoma, in which both melanocyte-targeted human BRAFV600E co-operates with tumor suppressor p19ARF loss (hereafter referred to as Arf−/−) to facilitate melanoma formation and AKT phosphorylation is observed in tumors but not normal skin [37]. This evidence concerns the gene CDKN2A and melanoma.