WWTR1 and cancer: (1) Wild type YAP and/or TAZ are often activated and overexpressed in cancer cells or cancer stem cells, as observed in human malignancies, including breast, liver, colon, prostate, pancreatic, ovarian, uterine, and renal carcinomas, as well as melanoma, sarcomas, and neuronal tumors [17,18,21,22,23,24,25,26,27,28,29,30,31].