WWTR1 and cancer: (2) Cancer-related point mutation(s) in the coding region of YAP/TAZ proteins per se seem exceedingly rare [32]; so far, the YAP1 R331W missense mutant was reported to predispose for lung adenocarcinoma [54] and activating somatic mutations of regulatory phosphorylation sites were detected in YAP in a melanoma patient [55].