Considering our comprehensive analysis of DNMT expressions across the progression of OEC, we hypothesize that DNMT1 and DNTM3A seem to play a role in tumor initiation, DNMT3B in tumor progression and DNMT3L in tumor relapse, whereas DNMT2 may have an opposite role, acting as a tumor-suppressor gene. This evidence concerns the gene DNMT3L and neoplasm.