DNMT3L and metastatic neoplasm: Additionally, the gene chip data (Figure 2) from the GEO series (TNMplot) indicated that DNMT3A (p < 0.0001), DNMT3B (p < 0.0001) and DNMT3L mRNA (p < 0.0001) expression was reduced in metastatic tumors compared to the primaries and almost reached the levels of normal tissues, while DNMT1 expression was maintained at high levels in metastasis and was not statistically different from that of the primary tumors.