After an immunohistochemical study of a patient cohort from our department and TNM plot, GEPIA2, Kaplan–Meier Plotter, TCGA and Proteomic data analysis for mRNA and protein expression of DNMTs (DNMTA, DNMT2, DNMT3A, DNMT3B and DNMT3L), it is obvious that DNMTs expression is altered in ovarian cancer tissues. Here, DNMT3B is linked to ovarian carcinoma.