SPOP and pachyonychia congenita: The hypothesis that SPOP-mutated PC is primarily driven by AR signaling was tested in a real-world setting: in a cohort of men with de novo mHSPC undergoing ADT plus NHA, the presence of SPOP mutation compared with wild-type was associated with a longer time to castration resistance and OS, while the SPOP mutational status was not associated with the time to castration resistance or OS in a cohort treated with ADT plus docetaxel [74].