Correspondingly, in GSE100550, a significant positive correlation of TGFB with HAVCR2, M2 macrophage and TBSS was specifically found in bulk CRC tissues (Spearman’s r: 0.5792–0.7909, p < 0.0001), but not in CRC organoids, xenografts or cell lines (Spearman’s r: −0.2239–0.3333) (Figure 3D–F). The gene discussed is HAVCR2; the disease is colorectal carcinoma.