Based on pairwise analysis of patient-derived CRC organoids and their matched CRC bulk tissues (GSE171862), we found that the levels of TGFB were significantly correlated with HAVCR2, M2 macrophage and TBSS in bulk tumor tissues (Spearman’s r: 0.6716–0.8463, p < 0.0001) but not in organoids (Spearman’s r: −0.01699–0.3112) (Figure 3A–C). Here, HAVCR2 is linked to neoplasm.