For example, our analysis showed that YY1 is an adverse prognostic factor in AML, B-cell lymphoma, DLBCL, colorectal cancer, uveal melanoma, lung cancer, ovarian cancer, skin cancer, and liposarcoma (p < 0.05, HR > 0) and a protective prognostic factor in astrocytoma, breast cancer, gliomas, ovarian cancer, B-cell lymphoma, breast cancer, and renal cell carcinoma (p < 0.05, HR < 0). The gene discussed is YY1; the disease is skin cancer.