YY1 and neoplasm: As such, and in support of its oncogenic function, YY1 has been shown to have proliferative and tumor promoting effects in several tumors, including gastric, breast, prostate, cervical, colon, neuroblastoma, and hepatocellular carcinomas [83,84], whereas in others, such as in pancreatic ductal adenocarcinoma, it can suppress the proliferation and migration of cancer cells [85].