In support of this notion, Vivarelli et al. recently reported that YY1 and RKIP expression are inversely correlated in lung cancer, as the computational analysis of the deposited YY1-ChIP-Seq experiments revealed a negative regulation of RKIP by YY1, suggesting that both genes can be used for predictive diagnostic and prognostic purposes in this malignancy [9]. This evidence concerns the gene YY1 and lung cancer.