Given that YY1 promotes the transcriptional activation of AR in prostate cells, which further cooperates with YY1 to activate expression of prostate specific antigen (PSA) and prostate stem cell antigen (PSCA), both known to contribute to prostate oncogenesis [94], a possible YY1/RKIP cross-talk in prostate cancer is also worth exploration [95]. The gene discussed is AR; the disease is prostate cancer.