Interestingly, among the underlying molecular signaling cascades currently suggested to mediate the RKIP activities in cancer cells, we have identified and proposed the dysregulation of the NF-κΒ/Snail/YY1/RKIP/PTEN circuitry, not only as an example of the RKIP/YY1 cross-talk in cancer cells, but also as a moderator and connector of several critical processes that take place in tumors, like autophagy, EMT, and resistance to apoptosis [87,88,89,90]. The gene discussed is PEBP1; the disease is cancer.