Corroborating our findings on the critical immunomodulatory role of YY1 in cancer progression, data derived by a recent pan-cancer analysis also demonstrate negative correlation between YY1 expression and infiltration of most immunoreactive cells, including CD8+ T cells, B cells, macrophages, dendritic cells, and neutrophils, in >10 different cancer tissues; while YY1 expression has been positively associated with the estimated infiltration value of cancer-associated fibroblasts [52]. Here, CD8A is linked to cancer.