For instance, genes encoding epigenetic modifying enzymes, including DNA (cytosine-5)-methyltransferase 3A (DNMT3A) and isocitrate dehydrogenase IDH1/2, were mutated at a high frequency in the founding clones of human acute myeloid leukemia (AML) [8,9]. This evidence concerns the gene DNMT3A and acute myeloid leukemia.