Differentially from DM types I and II, pancreatogenic DM is well tolerated, being fairly sensitive to insulin administration, and rarely develops ketoacidosis or severe hyperglycemia or hypoglycemia [32], as confirmed also by our study, in which, in all patients manifesting post-operative DM, the hormonal impairment resulted to be well controlled through insulin supplementation, with minimal affection on the quality of life of patients. This evidence concerns the gene INS and diabetes mellitus.