MEN1 and multiple endocrine neoplasia type 1: Considering the numerous variables that could influence the neoplastic progression of PNENs in MEN1, a clear answer of which is the best surgical strategy could be assessed via a prospective and randomized study, performed on MEN1 patients with PNENs between 1 and 2 cm, through evaluating tumoral outcomes after prophylactic surgery in one group of patients in comparison to a group of cases being only under surveillance.