AKT1 and cancer: They include AKT1/2/3, a serine-threonine protein kinase that promotes cell survival and growth, Cyclin D1, a protein that controls the progression of the cell cycle, p21, a protein that inhibits cell cycle progression, MMP9, an enzyme that helps break down the extracellular matrix, allowing cancer cells to invade and metastasize, and HOXA10, a transcription factor that regulates the expression of many genes involved in cell growth and differentiation.