Though the relationship between miR-665 and radio resistance is still unclear, studies have shown that miR-665 may inhibit cancer radio resistance by targeting key genes involved in the DNA damage response and repair pathway, such as p53 in NSCLC, B-cell lymphoma 2 protein (Bcl-2), which regulates programmed cell death, in hippocampal astrocytes, and ATM in GC [125,147,148], or increase radio resistance by regulating the MAPK pathway, including regulation of NR4A3, SRCIN1, and HOXA10/11 [19,26,149]. This evidence concerns the gene NR4A3 and cancer.