HMGB1 and neoplasm: Similarly, the INA:LX-2/XVir (140 d post-treatment)- and INA/IT combination (182 d post-treatment)-treated mice also showed HMGB1, HSP70 and YB-1 staining in the tumor, which, in most tumor areas, was more or less equally distributed, whereas in a few areas, like in LN-229GFP tumors at day 18 (Figure 3), hot spots of HMGB1 staining were visible (Figure 8, Supplementary Figure S4).